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LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (1)

Large tumor suppressor 1 (LATS1) is the key kinase controlling activation of Hippo signalling pathway. Post-translational modifications of LATS1 modul......

JIF:3.544

Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (10)

The gut microbiota is involved in host responses to high altitude. However, the dynamics of intestinal microecology and their association with altitud......

JIF:3.544

QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (12)

The soybean E1 gene is a major regulator that plays an important role in flowering time and maturity. However, it remains unclear how cultivars carryi......

JIF:3.544

Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (2)

Mitochondria, double-membrane organelles, are known to participate in a variety of metabolic and signal transduction pathways. The intermembrane space......

JIF:3.544

REG gamma drives Lgr5(+) stem cells to potentiate radiation induced intestinal regeneration

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (8)

Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), a marker of intestinal stem cells (ISCs), is considered to play key roles in tissu......

JIF:3.544

CRISPR-CasRx knock-in mice for RNA degradation

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (11)

The RNA editing tool CRISPR-CasRx has provided a platform for a range of transcriptome analysis tools and therapeutic approaches with its broad effica......

JIF:3.544

PDGFR kinase inhibitor protects against septic death via regulation of BTLA

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (10)

Sepsis, defined as life-threatening organ failure caused by a dysregulated host response to severe infection, is a major cause of death among intensiv......

JIF:3.544

A 5 ' tRNA-Ala-derived small RNA regulates anti-fungal defense in plants

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (1)

Apart from their primordial role in protein synthesis, tRNAs can be cleaved to produce tRNA-derived small RNAs (tsRNAs). The biological functions of t......

JIF:3.544

Functional microglia derived from human pluripotent stem cells empower retinal organ

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (6)

Microglia are known to play essential roles in the development, progression and treatment of diverse neurodegenerative diseases in the central nervous......

JIF:3.544

Compression loading of osteoclasts attenuated microRNA-146a-5p expression, which promotes angiogenesis by targeting adiponectin

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (1)

Osteoclastogenesis in alveolar bone induced by compression stress triggers orthodontic tooth movement. Compression stress also stimulates angiogenesis......

JIF:3.544

Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (1)

The iron oxide nanoparticles (IONPs) that combine the nanozyme activity and magnetothermal properties have attracted significant interest for various ......

JIF:3.544

Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma

期刊: SCIENCE CHINA-LIFE SCIENCES, 2022; 65 (1)

Adenosine-to-inosine (A-to-I) RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigene......

JIF:3.544

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