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Comprehensive genetic profiling of six pulmonary nuclear protein in testis carcinomas with a novel micropapillary histological subtype in two cases

期刊: HUMAN PATHOLOGY, 2021; 115 ()

Nuclear protein in testis (NUT) carcinoma (NC) is a rare and aggressive neoplasm associated with a rearrangement of the NUT gene on chromosome 15q14. ......

Dataset for the reporting of carcinoma of the esophagus in resection specimens: recommendations from the International Collaboration on Cancer Reporting

期刊: HUMAN PATHOLOGY, 2021; 114 ()

A Background and objectives: A standardized data set for esophageal carcinoma pathology reporting was developed based on the approach of the Internati......

Integrated clinicopathological and immunohistochemical analysis of gastric adenocarcinoma with hepatoid differentiation: an exploration of histogenesis, molecular characteristics, and prognostic markers

期刊: HUMAN PATHOLOGY, 2021; 115 ()

In addition to hepatoid adenocarcinoma (HAC), gastric adenocarcinoma with enteroblastic differentiation (GAED) and common adenocarcinoma (COM) could a......

Expression of B7-H4 and IDO1 is associated with drug resistance and poor prognosis in high-grade serous ovarian carcinomas

期刊: HUMAN PATHOLOGY, 2021; 113 ()

High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy. While immune checkpoint inhibitors against PD-L1 and CTLA-4 have......

Prognostic value of histopathologic pattern for long-term surgical outcomes of 198 patients with confirmed mesial temporal lobe epilepsy

期刊: HUMAN PATHOLOGY, 2021; 115 ()

Hippocampal sclerosis (HS) is the most common neuropathologic findings in patients with intractable temporal lobe epilepsy (TLE). The international le......

Identification of novel ALK fusions using DNA/ RNA sequencing in immunohistochemistry / RT-PCR discordant NSCLC patients

期刊: HUMAN PATHOLOGY, 2021; 114 ()

Anaplastic lymphocyte kinase (ALK ) rearrangement, a key oncogenic driver promoting the expression of ALK protein in tumor cells, is found in 2%-7% of......

Clinicopathological features and prognostic analysis of 247 small cell lung cancer with limited-stage after surgery

期刊: HUMAN PATHOLOGY, 2021; 108 ()

The objective of this study was to analyze the clinical and pathological characteristics of patients with small cell lung cancer (SCLC) after curative......

Prognostic and predictive values of the KIT11-mutated grading system in patients with gastrointestinal stromal tumors: a retrospective study

期刊: HUMAN PATHOLOGY, 2021; 110 ()

The KIT11 mutation is the most frequent mutation pattern in gastrointestinal stromal tumors (GISTs). However, few studies have investigated the correl......

ESR1 genetic alterations and their association with clinicopathologic characteristics in advanced breast cancer: a single academic institution experience

期刊: HUMAN PATHOLOGY, 2021; 107 ()

Estrogen receptor (ER) alpha, a ligand-dependent nuclear transcription factor encoded by the ESR1 gene, is expressed in 70% of breast carcinomas (BCs)......

Interobserver agreement in pathologic evaluation of bile duct biopsies

期刊: HUMAN PATHOLOGY, 2021; 107 ()

Intraductal biopsy is commonly used for preoperative evaluation of the etiology of biliary strictures. Interpretation of intraductal biopsies is frequ......

Decreased BIM expression in BCL2-negative follicular lymphoma: a potential mechanism for resistance to apoptosis

期刊: HUMAN PATHOLOGY, 2021; 107 ()

Follicular lymphoma (FL) is characterized by t(14; 18)(q32; q21), leading to overexpression of the antiapoptotic molecule BCL2; however, a subset of F......

Clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory updates bowel disease

期刊: HUMAN PATHOLOGY, 2020; 96 ()

Patients with inflammatory bowel disease (IBD) may occasionally present with lymphocytic colitis/collagenous colitis (LC/CC) either before or after th......

Stromal PD-1(+) tumor-associated macrophages predict poor prognosis in lung adenocarcinoma

期刊: HUMAN PATHOLOGY, 2020; 97 ()

Immunotherapies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand (PD-L1) axis have been emerging as a promising therapeutic strategy to tr......

Pathological prognostic factors of pseudomyxoma peritonei: comprehensive clinicopathological analysis of 155 cases

期刊: HUMAN PATHOLOGY, 2020; 97 ()

Background: Pseudomyxoma peritonei (PMP) is an extremely rare malignancy, characterized by extensive peritoneal implantation and colloidal ascites. Th......

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