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A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1

期刊: TRANSLATIONAL RESEARCH, 2022; 247 ()

Fungal infection threatens human health worldwide due to the limited arsenal of antifungals and the rapid emergence of resistance. Epidermal growth fa......

JIF:6.542

Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner

期刊: TRANSLATIONAL RESEARCH, 2022; 248 ()

Cardiac fibrosis is a process characterized by extracellular matrix accumulation leading to myocardial dysfunction. Angiotensin II (Ang II) has been s......

JIF:6.542

The proteasome activator REGg promotes diabetic endothelial impairment by inhibiting HMGA2-GLUT1 pathway

期刊: TRANSLATIONAL RESEARCH, 2022; 246 ()

Diabetic vascular endothelial impairment is one of the main causes of death in patients with diabetes lacking adequately defined mechanisms or effecti......

JIF:6.542

Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer

期刊: TRANSLATIONAL RESEARCH, 2021; 231 ()

Gastric cancer (GC) is a highly prevalent malignancy featured by dismal oncological outcomes. Accumulating pieces of evidence have consensus over the ......

Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling

期刊: TRANSLATIONAL RESEARCH, 2021; 233 ()

Heart failure is one of the leading causes of death worldwide. A stimulated heart undergoes either adaptive physiological hypertrophy, which can maint......

Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF

期刊: TRANSLATIONAL RESEARCH, 2021; 235 ()

Traumatic brain injury (TBI) is one of the leading causes of disability and paralysis around the world. Secondary injury, characterized by progressive......

Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling

期刊: TRANSLATIONAL RESEARCH, 2021; 233 ()

Activation of the innate immune system represents a vital step in inflammation during cardiac remodeling induced by the angiotensin II (Ang II). This ......

Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells

期刊: TRANSLATIONAL RESEARCH, 2021; 235 ()

Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by vascular dysplasia. Mutations of the endoglin (ENG) gene that encode......

Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation

期刊: TRANSLATIONAL RESEARCH, 2021; 233 ()

Clinical observation and ex vivo studies have established a strong association between inflammation and postoperative atrial fibrillation (POAF). Howe......

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension

期刊: TRANSLATIONAL RESEARCH, 2021; 233 ()

Ophiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert antiproliferative and antitissue remodeling effects. Vascular remodeling ......

Targeting T-type/CaV3.2 channels for chronic pain

期刊: TRANSLATIONAL RESEARCH, 2021; 234 ()

Abbreviations: AP = action potentials; CaV3.2 = voltage-gated calcium channel subfamily CaV3.2; CCD = chronic compression of DRG; CCI = chronic constr......

Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients

期刊: TRANSLATIONAL RESEARCH, 2021; 233 ()

The gonadotropin-releasing hormone (GnRH) signaling pathway controls reproductive functions and cancer growth and progression. However, few studies in......

Identification of novel therapeutic targets for contrast induced acute kidney injury (CI-AKI): alpha blockers as a therapeutic strategy for CI-AKI

期刊: TRANSLATIONAL RESEARCH, 2021; 235 ()

Iodinated contrast is used for imaging and invasive procedures and it can cause contrast induced acute kidney injury (CI-AKI), which is the third lead......

IcyHot analgesic topical cream limits cardiac injury in rodents

期刊: TRANSLATIONAL RESEARCH, 2021; 227 ()

Little is known whether topical analgesic creams, whose natural products enter the blood stream after application, affect myocardial infarct size. Her......

Downregulating the P2X3 receptor in the carotid body to reduce blood pressure via acoustic gene delivery in canines

期刊: TRANSLATIONAL RESEARCH, 2021; 227 ()

The purinergic P2X3 receptor in the carotid body (CB) is considered a new target for treating hypertension, although approaches for targeted regulatin......

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