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The Differentiation of Pluripotent Stem Cells towards Endothelial Progenitor Cells - Potential Application in Pulmonary Arterial Hypertension

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Endothelial progenitor cells (EPCs) and endothelial cells (ECs) have been applied in the clinic to treat pulmonary arterial......

Single-Cell RNA Sequencing of Bone Marrow Mesenchymal Stem Cells from the Elderly People

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Bone marrow mesenchymal stem cells (BMSCs) show considerable promise in regenerative medicine. Many studies demonstrated th......

Human Umbilical Cord Mesenchymal Stem Cells Improve the Necrosis and Osteocyte Apoptosis in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Model through Reducing the Macrophage Polarization

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Apoptosis is an outstanding determinant of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Human umbi......

BMP-6 Attenuates Oxygen and Glucose Deprivation-Induced Apoptosis in Human Neural Stem Cells through Inhibiting p38 MAPK Signaling Pathway

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Neural stem cells (NSCs) remain in the mammalian brain throughout life and provide a novel therapeutic strategy for central......

Evaluation of Circulating Endothelial Progenitor Cells in Abdominal Aortic Aneurysms after Endovascular Aneurysm Repair

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Circulating endothelial progenitor cells (EPCs) participate in vascular repair and predict cardiovascular outcomes. The aim......

Effects and Mechanisms of Bone Marrow Mesenchymal Stem Cell Transplantation for Treatment of Ischemic Stroke in Hypertensive Rats

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Stroke is the most common cause of human death and functional disability, resulting in more than 5 million deaths worldwide......

Psoriatic Serum Induce an Abnormal Inflammatory Phenotype and a Decreased Immunosuppressive Function of Mesenchymal Stem Cells

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Mesenchymal stem cells (MSCs) have immunomodulatory function and participate in the pathogenesis of many immunoregulation-r......

Pharmaceutical Activation of Nrf2 Accelerates Diabetic Wound Healing by Exosomes from Bone Marrow Mesenchymal Stem Cells

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2022; 15 (2)

Background and Objectives: Despite advances in wound treatments, chronic diabetic wounds remain a significant medical challenge. Exosomes from mesench......

Improved Differentiation Ability and Therapeutic Effect of miR-23a-3p Expressing Bone Marrow-Derived Mesenchymal Stem Cells in Mice Model with Acute Lung Injury

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (2)

Background and Objectives: Implantation of bone marrow-derived mesenchymal stem cells (BMSCs) has been recognized as an effective therapy for attenuat......

Role of miRNA-324-5p-Modified Adipose-Derived Stem Cells in Post-Myocardial Infarction Repair

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (3)

Background and Objectives: To seek out the role of mircoRNA (miR)-324-5p-modified adipose-derived stem cells (ADSCs) in post-myocardial infarction (MI......

Valproic Acid Enhance Reprogramming of Bactrian Camel Cells through Promoting the Expression of Endogenous Gene c-Myc and the Process of Angiogenesis

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (2)

Background and Objectives: Induced pluripotent stem cells (iPSCs) are usually generated by reprogramming differentiated cells through the introduction......

Organoids: A New Model for SARS-CoV-2 Translational Research

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (2)

The 2019-novel coronavirus (SARS-CoV-2) pneumonia epidemic is a thorny public health problem faced by health officials and a major cause of concern fo......

Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (3)

Background and Objectives: Systemic scleroderma (SSc) is a rare and serious connective tissue disease, an autoimmune disease, and a rare refractory di......

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Regulate Macrophage Polarization to Attenuate Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage in Mice

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (3)

Background and Objectives: To investigate the effect and the underlying mechanism of exosomes secreted by human umbilical cord mesenchymal stem cells ......

Vascularized Organoids: A More Complete Model

期刊: INTERNATIONAL JOURNAL OF STEM CELLS, 2021; 14 (2)

As an emerging research model in vitro, organoids have achieved major progress in recapitulating morphological aspects of organs and personalized prec......

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