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Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology

Macabuag, N; Esmieu, W; Breccia, P; Jarvis, R; Blackaby, W; Lazari, O; Urbonas, L; Eznarriaga, M; Williams, R; Strijbosch, A; van de Bospoort, R; Matthews, K; Clissold, C; Ladduwahetty, T; Vater, H; Heaphy, P; Stafford, DG; Wang, HJ; Mangette, JE; McAllister, G; Beaumont, V; Vogt, TF; Wilkinson, HA; Doherty, EM; Dominguez, C

Doherty, EM (通讯作者),CHDI Management CHDI Fdn, Los Angeles, CA 90045 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (18): 12445

Abstract

Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (HTT) gene......

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