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DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression

Appiah, B; Fullio, CL; Ossola, C; Bertani, I; Restelli, E; Cheffer, A; Polenghi, M; Haffner, C; Garcia-Miralles, M; Zeis, P; Treppner, M; Bovio, P; Schlichtholz, L; Mas-Sanchez, A; Zografidou, L; Winter, J; Binder, H; Grün, D; Kalebic, N; Taverna, E; Vogel, T

Vogel, T (通讯作者),Albert Ludwigs Univ Freiburg, Inst Anat & Cell Biol, Fac Med, Dept Mol Embryol, Freiburg, Germany.;Taverna, E (通讯作者),Human Technopole, Milan, Italy.;Vogel, T (通讯作者),Albert Ludwigs Univ Freiburg, Med Fac, Ctr Basics NeuroModulat NeuroModul Basics, Freiburg, Germany.;Vogel, T (通讯作者),Albert Ludwigs Univ Freiburg, Freiburg Inst Adv Studies FRIAS, Freiburg, Germany.

EMBO REPORTS, 2023; 24 (8):

Abstract

Cortical neurogenesis depends on the balance between self-renewal and differentiation of apical progenitors (APs). Here, we study the epigenetic contr......

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