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A positive genetic selection for transmembrane domain mutations in HRD1 underscores the importance of Hrd1 complex integrity during ERAD

Nakatsukasa, K; Wigge, S; Takano, Y; Kawarasaki, T; Kamura, T; Brodsky, JL

Nakatsukasa, K (通讯作者),Nagoya City Univ, Grad Sch Sci, Mizuho Ku, Yamanohata 1, Nagoya, Aichi 4678501, Japan.;Brodsky, JL (通讯作者),Univ Pittsburgh, Dept Biol Sci, A320 Langley Hall, Pittsburgh, PA 15260 USA.

CURRENT GENETICS, 2022; 68 (2): 227

Abstract

Misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytosol for ubiquitination and degradation by the proteasome. During......

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