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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Solomon, BJ; Tan, L; Lin, JJ; Wong, SQ; Hollizeck, S; Ebata, K; Tuch, BB; Yoda, S; Gainor, JF; Sequist, LV; Oxnard, GR; Gautschi, O; Drilon, A; Subbiah, V; Khoo, C; Zhu, EY; Nguyen, M; Henry, D; Condroski, KR; Kolakowski, GR; Gomez, E; Ballard, J; Metcalf, AT; Blake, JF; Dawson, SJ; Blosser, W; Stancato, LF; Brandhuber, BJ; Andrews, S; Robinson, BG; Rothenberg, SM

Solomon, BJ (corresponding author), Peter MacCallum Canc Ctr, Dept Med Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia.

Abstract

Introduction: Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unpreceden......

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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

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