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Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation

Li, T; Fu, B; Zhang, X; Zhou, YJ; Yang, MD; Cao, MR; Chen, YX; Tan, YY; Hu, R

Hu, R (corresponding author), China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Physiol, 24 Tongjia Xiang, Nanjing 210009, Jiangsu, Peoples R China.

CANCER IMMUNOLOGY RESEARCH, 2021; 9 (9): 1008

Abstract

Chronic inflammation is a key driver for colitis-associated colorectal cancer. 5-hydroxytryptarnine (5-HT), a neurotransmitter, has been reported to p......

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