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CHMFL-BMX-078, a BMX inhibitor, overcomes the resistance of melanoma to vemurafenib via inhibiting AKT pathway

Jiang, SL; Jiang, T; Huang, HX; Chen, XS; Li, LY; Wang, ZB; Fei, JF; Liu, C; Liu, ZQ; Cheng, Y

Liu, ZQ (通讯作者),Cent South Univ, Dept Clin Pharmacol, Hunan Key Lab Pharmacogenet, Xiangya Hosp, Changsha 410008, Peoples R China.;Cheng, Y (通讯作者),Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

CHEMICO-BIOLOGICAL INTERACTIONS, 2022; 351 ():

Abstract

Our recent study demonstrated eIF3a loss contributes to vemurafenib resistance in melanoma by activating ERK. However, overexpression of eIF3a in the ......

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