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The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes

Lv, M; Cai, YZ; Hou, WK; Peng, K; Xu, K; Lu, C; Yu, WX; Zhang, WS; Liu, L

Liu, L (通讯作者),Xi An Jiao Tong Univ, Honghui Hosp, Osteonecrosis & Joint Reconstruct Ward, 555 Youyi East Rd, Xian 710054, Peoples R China.

INFLAMMATION RESEARCH, 2022; 71 (4): 461

Abstract

Background Heat shock protein family A member 5 (HSPA5), a recently identified suppressor of ferroptosis, was reported to potentially regulating osteo......

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