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Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R-YAP Axis

Zhu, H; Wang, DD; Yuan, T; Yan, FJ; Zeng, CM; Dai, XY; Chen, ZB; Chen, Y; Zhou, TY; Fan, GH; Ying, MD; Cao, J; Luo, PH; Liu, XJ; Hu, YD; Peng, Y; He, QJ; Yang, B

He, QJ; Yang, B (reprint author), Zhejiang Univ, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.

CANCER RESEARCH, 2018; 78 (14): 3995

Abstract

Given that Yes-associated protein (YAP) signaling acts as a critical survival input for hypoxic cancer cells in hepatocellular carcinoma (HCC), disrup......

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