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Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities

El-Miligy, MMM; Abdelaziz, ME; Fahmy, SM; Ibrahim, TM; Abu-Serie, MM; Mahran, MA; Hazzaa, AA

El-Miligy, MMM; Abdelaziz, ME (通讯作者),Alexandria Univ, Fac Pharm, Pharmaceut Chem Dept, 1st El khartoum Sq, Alexandria 21521, Egypt.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1):

Abstract

New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low......

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