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IL-17-receptor-associated adaptor Acti directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

Herjan, T; Hong, LZ; Bubenik, J; Bulek, K; Qian, W; Liu, CN; Li, X; Chen, X; Yang, H; Ouyang, SD; Zhou, H; Zhao, JJ; Vasu, K; Cockman, E; Aronica, M; Asosingh, K; Licatalosi, DD; Qin, J; Fox, PL; Hamilton, TA; Driscol, D; Li, XX

Li, XX (reprint author), Cleveland Clin Fdn, Dept Immunol, Lerner Res Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA.

NATURE IMMUNOLOGY, 2018; 19 (4): 354

Abstract

Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleu......

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