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NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Steinke, S; Kirmann, T; Loi, EA; Nerlich, J; Weichard, I; Kuhn, P; Bullmann, T; Ritzau-Jost, A; Rizalar, FS; Prüss, H; Haucke, V; Geis, C; Hust, M; Hallermann, S

Geis, C (通讯作者)，Jena Univ Hosp, Dept Neurol, Sect Translat Neuroimmunol, Kastanienstr 1, Jena, Germany.;Hust, M (通讯作者)，Tech Univ Carolo Wilhelmina Braunschweig, Inst Biochem Biotechnol & Bioinformat, Dept Med Biotechnol, Spielmannstr 7, D-38106 Braunschweig, Germany.;Hallermann, S (通讯作者)，Univ Leipzig, Carl Ludwig Inst Physiol, Fac Med, Liebigstr 27, D-04103 Leipzig, Germany.

BRAIN, 2023; 146 (5): 1812

Abstract

Steinke et al. develop and validate a construct that neutralizes autoantibodies from patients with NMDAR encephalitis, and prevents receptor internali......

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