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Discovery of a novel potent GPR40 full agonist

Meegalla, SK; Huang, H; Martin, T; Xu, JN; Zhao, SY; Liu, JY; Hall, M; Gunnet, J; Wang, YP; Rady, B; Silva, J; Otieno, M; Arnoult, E; Lee, SP; Pocai, A; Player, MR

Player, MR (reprint author), Janssen Res & Dev LLC, CVM Discovery, Welsh & McKean Rd, Spring House, PA 19477 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018; 28 (4): 720

Abstract

Compound 12 is a GPR40 agonist that realizes the full magnitude of efficacy possible via GPR40 receptor agonism. In vitro and in vivo studies demonstr......

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