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Activation by substoichiometric inhibition

Merdanovic, M; Burston, SG; Schmitz, AL; Kocher, S; Knapp, S; Clausen, T; Kaiser, M; Huber, R; Ehrmann, M

Huber, R; Ehrmann, M (corresponding author), Univ Duisburg Essen, Ctr Med Biotechnol, Fac Biol, D-45117 Essen, Germany.; Huber, R (corresponding author), Max Planck Inst Biochem, D-82152 Martinsried, Germany.; Ehrmann, M (corresponding author), Cardiff Univ, Sch Biosci, Cardiff CF10 3US, Wales.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020; 117 (3): 1414

Abstract

Startling reports described the paradoxical triggering of the human mitogen-activated protein kinase pathway when a small-molecule inhibitor specifica......

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