Pharmacological assessment of the antineoplastic and immunomodulatory properties of a new spiroindolone derivative (7',8'-Dimethoxy-1',3'-dimethyl-1,2,3',4'-tetrahydrospiro[indole-3,5'-pyrazolo[3,4-c]isoquinolin]-2-one) in chronic myeloid leukemia-MedSci.cn

Pharmacological assessment of the antineoplastic and immunomodulatory properties of a new spiroindolone derivative (7',8'-Dimethoxy-1',3'-dimethyl-1,2,3',4'-tetrahydrospiro[indole-3,5'-pyrazolo[3,4-c]isoquinolin]-2-one) in chronic myeloid leukemia

Alves, CED; Bogza, SL; Bohdan, N; Rozhenko, AB; Gomes, AD; de Oliveira, RC; de Azevedo, RG; Maciel, LRS; Dhyani, A; Grafov, A; Pontes, GS

Pontes, GS (通讯作者)，Univ Fed Amazonas, Inst Biol Sci, Postgrad Program Basic & Appl Immunol, BR-69077000 Manaus, AM, Brazil.;Pontes, GS (通讯作者)，Natl Inst Amazonian Res INPA, Lab Virol & Immunol, BR-69067375 Manaus, AM, Brazil.;Pontes, GS (通讯作者)，Univ Estado Amazonas, Fdn Hematol & Hemotherapy Amazonas, Postgrad Program Hematol, BR-69050010 Manaus, AM, Brazil.

Abstract

The discovery and development of effective novel compounds is paramount in oncology for improving cancer therapy. In this study, we developed a new de......

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Pharmacological assessment of the antineoplastic and immunomodulatory properties of a new spiroindolone derivative (7',8'-Dimethoxy-1',3'-dimethyl-1,2,3',4'-tetrahydrospiro[indole-3,5'-pyrazolo[3,4-c]isoquinolin]-2-one) in chronic myeloid leukemia

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