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Loopholes in the DNA contract kill neurons

Herrup, K; Tse, KH; Chow, HM

Herrup, K (reprint author), Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China.; Herrup, K (reprint author), Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China.

NATURE NEUROSCIENCE, 2017; 20 (9): 1192

Abstract

Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA-RNA R-loops that spawn double-strand breaks and......

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