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A gemcitabine-based conjugate with enhanced antitumor efficacy by suppressing HIF-1 alpha expression under hypoxia

Xu, ZC; Zhang, B; Liao, ZX; Gou, SH

Liao, ZX; Gou, SH (corresponding author), Southeast Univ, Pharmaceut Res Ctr, Nanjing 211189, Peoples R China.; Liao, ZX; Gou, SH (corresponding author), Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 41 ():

Abstract

Hypoxia is one of the unique features of tumor physiology. Hypoxia inducible factor (HIF-1 alpha), as a major transcription factor in response to hypo......

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