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SECAT: Quantifying Protein Complex Dynamics across Cell States by Network-Centric Analysis of SEC-SWATH-MS Profiles

Rosenberger, G; Heusel, M; Bludau, I; Collins, B; Martelli, C; Williams, EG; Xue, P; Liu, YS; Aebersold, R; Califano, A

Califano, A (corresponding author), Columbia Univ, Dept Syst Biol, New York, NY 10027 USA.; Aebersold, R (corresponding author), Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland.; Califano, A (corresponding author), Columbia Univ, Dept Biomed Informat, New York, NY 10027 USA.; Califano, A (corresponding author), Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10027 USA.; Califano, A (corresponding author), Columbia Univ, JP Sulzberger Columbia Genome Ctr, New York, NY 10027 USA.; Califano, A (corresponding author), Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10027 USA.; Califano, A (corresponding author), Columbia Univ, Dept Med, Vagelos Coll Phys & Surg, New York, NY 10027 USA.

CELL SYSTEMS, 2020; 11 (6): 589

Abstract

Protein-protein interactions (PPIs) play critical functional and regulatory roles in cellular processes. They are essential for macromolecular complex......

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