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Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics

Klug, DM; Tschiegg, L; Diaz, R; Rojas-Barros, D; Perez-Moreno, G; Ceballos, G; Garcia-Hernandez, R; Martinez-Martinez, MS; Manzano, P; Ruiz, LM; Caffrey, CR; Gamarro, F; Pacanowska, DG; Ferrins, L; Navarro, M; Pollastri, MP

Pollastri, MP (corresponding author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2020; 63 (5): 2527

Abstract

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by infection with either of two subspecies of the parasite Trypanosoma bruc......

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