METTL3 inhibition reduces N-6-methyladenosine levels and prevents allogeneic CD4(+) T-cell responses-MedSci.cn

METTL3 inhibition reduces N-6-methyladenosine levels and prevents allogeneic CD4(+) T-cell responses

Li, S; Zou, DW; Chen, WH; Britz, GW; Liu, ZQ; Weng, YL

Liu, ZQ (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Hunan Key Lab Pharmacogenet, 87 Xiangya Rd, Changsha 410008, Peoples R China.;Liu, ZQ (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, 87 Xiangya Rd, Changsha 410008, Peoples R China.;Weng, YL (通讯作者)，Houston Methodist Neurol Inst, Dept Neurosurg, 6670 Bertner Ave, Houston, TX 77030 USA.;Weng, YL (通讯作者)，Houston Methodist Res Inst, Ctr Neuroregenerat, 6670 Bertner Ave, Houston, TX 77030 USA.

Abstract

Alloreactive CD4(+) T cells play a central role in allograft rejection. However, the post-transcriptional regulation of the effector program in allore......

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METTL3 inhibition reduces N-6-methyladenosine levels and prevents allogeneic CD4(+) T-cell responses

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