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BCL-X-L directly modulates RAS signalling to favour cancer cell stemness

Trecesson, SD; Souaze, F; Basseville, A; Bernard, AC; Pecot, J; Lopez, J; Bessou, M; Sarosiek, KA; Letai, A; Barille-Nion, S; Valo, I; Coqueret, O; Guette, C; Campone, M; Gautier, F; Juin, PP

Juin, PP (reprint author), Univ Nantes Angers, IRT, Team Stress Adaptat & Tumor Escape 8, Inst Rech Sante,CRCINA, BP 70721,8 Quai Moncousu, F-44007 Nantes, France.; Juin, PP (reprint author), ICO Site Rene Gauducheau, Blvd Jacques Monod, F-44805 St Herbla

NATURE COMMUNICATIONS, 2017; 8 ( ):

Abstract

In tumours, accumulation of chemoresistant cells that express high levels of anti-n/apoptotic proteins such as BCL-n/X-L is thought to result from the......

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