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Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation

Kalvala, AK; Yerra, VG; Sherkhane, B; Gundu, C; Arruri, V; Kumar, R; Kumar, A

Kumar, A (corresponding author), Natl Inst Pharmaceut Educ & Res NIPER Hyderabad, Dept Pharmacol & Toxicol, Hyderabad 500037, Telangana, India.

PHARMACOLOGICAL REPORTS, 2020; 72 (6): 1627

Abstract

Background Disturbed mitochondrial homeostasis has been identified to contribute to the pathogenesis of diabetic neuropathy (DN). However, the role of......

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