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Conformationally restricted quinazolone derivatives as PI3K-selective inhibitors: the design, synthesis and biological evaluation

Ma, XD; Fang, F; Tao, QQ; Shen, L; Zhong, GC; Qiao, T; Lv, XQ; Li, JM

Li, JM (reprint author), Anhui Univ Chinese Med, Sch Pharm, Hefei 230031, Anhui, Peoples R China.; Li, JM (reprint author), Anhui Acad Chinese Med, Dept Med Chem, Hefei 230031, Anhui, Peoples R China.; Lv, XQ (reprint author), Jiaxing Univ, Coll Med, Jiax

MEDCHEMCOMM, 2019; 10 (3): 413

Abstract

A series of structurally novel quinazolone-based PI3K-selective inhibitors were designed and synthesized via the approach of conformational restrictio......

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