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Activated CTLA-4-independent immunosuppression of Treg cells disturbs CTLA-4 blockade-mediated antitumor immunity

Watanabe, T; Ishino, T; Ueda, Y; Nagasaki, J; Sadahira, T; Dansako, H; Araki, M; Togashi, Y

Togashi, Y (通讯作者),Okayama Univ, Fac Med Dent & Pharmaceut Sci, Dept Tumor Microenvironm, 2-5-1 Shikata cho, Kita ku, Okayama 7008558, Japan.

CANCER SCIENCE, 2023; 114 (5): 1859

Abstract

Combination therapy with anti-cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death-1 (PD-1) monoclonal antibodies (mAbs) has......

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