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Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses

Fu, ZP; Zhang, T; Zhou, ZX; Kang, DW; Sun, L; Gao, SH; Cherukupalli, S; De Clercq, E; Pannecouque, C; Liu, XY; Zhan, P

Pannecouque, C; Liu, XY; Zhan, P (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 42 ():

Abstract

To further explore the chemical space surrounding the "hydrophobic channel" of the NNRTI binding pocket (NNIBP), a new series of diarylpyrimidines (DA......

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