Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain derived neurotrophic factor (BDNF) expression level in the hippocampus-MedSci.cn

Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain derived neurotrophic factor (BDNF) expression level in the hippocampus

Wu, CH; Wang, Y; He, Y; Wu, S; Xie, ZF; Zhang, J; Shen, JS; Wang, Z; He, L

He, L (corresponding author), China Pharmaceut Univ, Dept Pharmacol, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.; Wang, Z (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China.

Abstract

Clinical and preclinical researches have shown that sub-anesthetic ketamine elicits sustained antidepressant effects for up to 1-2 weeks. Pharmacokine......

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Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain derived neurotrophic factor (BDNF) expression level in the hippocampus

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