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A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

Yang, E; Metzloff, M; Langmuller, AM; Xu, XJ; Clark, AG; Messer, PW; Champer, J

Champer, J (通讯作者),Peking Univ, Ctr Bioinformat, Peking Tsinghua Ctr Life Sci, Sch Life Sci, Beijing 100871, Peoples R China.

G3-GENES GENOMES GENETICS, 2022; 12 (6):

Abstract

Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially b......

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