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Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio

Tang, XH; Ning, MM; Ye, YL; Gu, YP; Yan, HY; Leng, Y; Shen, JH

Leng, Y; Shen, JH (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med SIMM, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 43 ():

Abstract

The farnesoid X receptor (FXR) is a promising therapeutic target for nonalcoholic steatohepatitis (NASH) and other bile acid related diseases because ......

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