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Autophagy-Sirt3 axis decelerates hematopoietic aging

Fang, YX; An, N; Zhu, LJ; Gu, Y; Qian, JW; Jiang, GY; Zhao, RJ; Wei, W; Xu, L; Zhang, GC; Yao, XY; Yuan, N; Zhang, SP; Zhao, Y; Wang, JR

Wang, JR (corresponding author), Soochow Univ, Sch Med,Dept Hematol,Inst Blood & Marrow Transpla, Hematol Ctr,Cyrus Tang Med Inst,Jiangsu Inst Hema, Collaborat Innovat Ctr Hematol,Affiliated Hosp 1, Suzhou 215006, Peoples R China.

AGING CELL, 2020; 19 (10):

Abstract

Autophagy suppresses mitochondrial metabolism to preserve hematopoietic stem cells (HSCs) in mice. However, the mechanism by which autophagy regulates......

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