HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression-MedSci.cn

HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression

Yang, F; Sun, R; Hou, Z; Zhang, FL; Xiao, Y; Yang, YS; Yang, SY; Xie, YF; Liu, YY; Luo, C; Liu, GY; Shao, ZM; Li, DQ

Liu, GY; Shao, ZM; Li, DQ (通讯作者)，Fudan Univ, Shanghai Canc Ctr, Shanghai 200032, Peoples R China.;Liu, GY; Shao, ZM; Li, DQ (通讯作者)，Fudan Univ, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab, Minist Sci & Technol,Inst Biomed Sci, Shanghai 200032, Peoples R China.

Abstract

Aims MORC family CW-type zinc finger 2 (MORC2), a GHKL-type ATPase, is aberrantly upregulated in multiple types of human tumors with profound effects ......

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HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression

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