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Serum levels of the IgA isotype switch factor TGF-beta 1 are elevated in patients with COVID-19

Wang, EY; Chen, H; Sun, BQ; Wang, H; Qu, HQ; Liu, YC; Sun, XZ; Qu, JC; Fang, ZF; Tian, LF; Zeng, YF; Huang, SK; Hakonarson, H; Liu, ZG

Hakonarson, H (corresponding author), Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA.; Liu, ZG (corresponding author), Shenzhen Univ, Sch Med, State Key Lab Resp Dis Allergy, 1066 Xueyuan Rd, Nanshan Dist Of Shenzhen 518061, Peoples R China.; Hakonarson, H (corresponding author), Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.; Huang, SK (corresponding author), Natl Hlth Res Inst, Natl Inst Environm Hlth Sci, Miaoli, Taiwan.

FEBS LETTERS, 2021; 595 (13): 1819

Abstract

We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of ......

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