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Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects

Han, YF; Huang, DS; Xu, SC; Li, LL; Tian, Y; Li, S; Chen, C; Li, YX; Sun, YP; Hou, YL; Sun, YJ; Qin, MZ; Gong, P; Gao, ZB; Zhao, YF

Zhao, YF (corresponding author), Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 103 Wenhua Rd, Shenyang 110016, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 212 ():

Abstract

Inhibition of the soluble epoxide hydrolase (sEH) is a promising new therapeutic approach in the treatment of inflammation. Driven by the in-house dat......

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