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Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding

Schmeing, S; Amrahova, G; Bigler, K; Chang, JY; Openy, J; Pal, S; Posada, L; Gasper, R; Hart, P

Hart, P (通讯作者),Max Planck Inst Mol Physiol, Chem Genom Ctr Max Planck Soc, Otto Hahn Str 11, D-44227 Dortmund, Germany.

CHEMICAL SCIENCE, 2023; 14 (31): 8269

Abstract

The diverse role of the splicing factor PTBP1 in human cells has been widely studied and was found to be a driver for several diseases. PTBP1 binds RN......

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