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Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

da Silva, LAG; Simonetti, F; Hutten, S; Riemenschneider, H; Sternburg, EL; Pietrek, LM; Gebel, J; Dotsch, V; Edbauer, D; Hummer, G; Stelzl, LS; Dormann, D

Dormann, D (通讯作者),Johannes Gutenberg Univ JGU, Inst Mol Physiol, Bioctr, Mainz, Germany.;Dormann, D (通讯作者),Munich Cluster Syst Neurol SyNergy Munich, Munich, Germany.;Dormann, D (通讯作者),Inst Mol Biol IMB, Mainz, Germany.

EMBO JOURNAL, 2022; 41 (8):

Abstract

Post-translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in neur......

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