Efficient preparation of the chiral intermediate of luliconazole with Lactobacillus kefir alcohol dehydrogenase through rational rearrangement of the substrate binding pocket-MedSci.cn

Efficient preparation of the chiral intermediate of luliconazole with Lactobacillus kefir alcohol dehydrogenase through rational rearrangement of the substrate binding pocket

Zheng, CN; Wang, ZG; Wang, Q; Wang, SY; Lao, SH; He, J; Chen, ZM

Wang, ZG; Chen, ZM (corresponding author), Hangzhou Normal Univ, Coll Life & Environm Sci, Lab Biocatalysis, Hangzhou 311121, Zhejiang, Peoples R China.; Wang, ZG (corresponding author), Hangzhou Normal Univ, Sch Med, Inst Ageing Res, Hangzhou 311121, Zhejiang, Peoples R China.

Abstract

Luliconazole has been approved by the FDA for fungal infection therapy because of its broad-spectrum antifungal activity. However, low efficiency and ......

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Efficient preparation of the chiral intermediate of luliconazole with Lactobacillus kefir alcohol dehydrogenase through rational rearrangement of the substrate binding pocket

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