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Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. alpha-Lipoic acid as a potential anti-copper agent

Smirnova, J; Kabin, E; Jarving, I; Bragina, O; Tougu, V; Plitz, T; Palumaa, P

Palumaa, P (reprint author), Tallinn Univ Technol, Dept Chem & Biotechnol, Akadeemia Tee 15, EE-12618 Tallinn, Estonia.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

Wilson disease is an autosomal recessive genetic disorder caused by loss-of-function mutations in the P-type copper ATPase, ATP7B, which leads to toxi......

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