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A 2 & PRIME;-modified uridine analog, 2'-O-(methylthiomethoxy)methyl uridine, for siRNA applications

Lyu, F; An, S; Kobayashi, Y; Nomura, K; Baba, R; Abe, N; Hiraoka, H; Hashiya, F; Shu, ZM; Ui-Tei, K; Kimura, Y; Abe, H

Abe, H (通讯作者),Nagoya Univ, Grad Sch Sci, Dept Chem, Furo Cho,Chikusa Ku, Nagoya, Aichi 4648602, Japan.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022; 74 ():

Abstract

The medicinal applications of siRNAs have been intensively examined but are still hindered by their low mo-lecular stability under biological conditio......

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