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Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS

Xu, L; Li, R; Li, J; Dong, Z; Zong, JX; Tan, CC; Ye, ZK; Shi, L; Gong, XX; Li, CJ

Xu, L (通讯作者),Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China.;Xu, L (通讯作者),Nanjing Med Univ, Affiliated Sir Run Run Hosp, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China.

JOURNAL OF BIOMEDICAL RESEARCH, 2022; 36 (2): 109

Abstract

Clopidogrel is a pro-drug which needs two-step metabolism to produce the active thiol metabolite. This study aimed to explore an efficient method to s......

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