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Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data

Nielsen, EI; Khan, DD; Cao, S; Lustig, U; Hughes, D; Andersson, DI; Friberg, LE

Nielsen, EI (reprint author), Uppsala Univ, Dept Pharmaceut Biosci, Box 591, SE-75124 Uppsala, Sweden.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017; 72 (11): 3108

Abstract

Background: Pharmacokinetic/pharmacodynamic (PKPD) models developed based on data from in vitro time-kill experiments have been suggested to contribut......

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