A negative feedback loop involving NF-kappa B/TIR8 regulates IL-1 beta-induced epithelial- myofibroblast transdifferentiation in human tubular cells-MedSci.cn

A negative feedback loop involving NF-kappa B/TIR8 regulates IL-1 beta-induced epithelial- myofibroblast transdifferentiation in human tubular cells

Jiang, KG; Zhang, YY; He, F; Zhang, MM; Li, TY; Tu, ZZ; Xu, DP; Zhang, M; Han, LZ; Guo, LY; Zhou, HS; Wang, DG

Wang, DG (corresponding author), Anhui Med Univ AHMU, Affiliated Hosp 2, Dept Nephrol, 678 Fu Rong Rd, Hefei, Peoples R China.; Zhou, HS (corresponding author), AHMU, Dept Biochem & Mol Biol, 69 Mei Shan Rd, Hefei, Peoples R China.; Zhou, HS (corresponding author), AHMU, Ctr Sci Res, 69 Mei Shan Rd, Hefei, Peoples R China.

Abstract

Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The pr......

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A negative feedback loop involving NF-kappa B/TIR8 regulates IL-1 beta-induced epithelial- myofibroblast transdifferentiation in human tubular cells

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