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Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

Qin, KH; Huang, P; Feng, RP; Keller, CA; Peslak, SA; Khandros, E; Saari, MS; Lan, XJ; Mayuranathan, T; Doerfler, PA; Abdulmalik, O; Giardine, B; Chou, ST; Shi, JW; Hardison, RC; Weiss, MJ; Blobel, GA

Blobel, GA (通讯作者),Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA.;Blobel, GA (通讯作者),Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.

NATURE GENETICS, 2022; 54 (6): 874

Abstract

The mechanisms by which the fetal-type beta-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental quest......

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