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Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver-alpha-cell axis

Liu, QF; Lin, GY; Chen, Y; Feng, WB; Xu, YN; Lyu, JJ; Yang, DH; Wang, MW

Wang, MW (corresponding author), Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China.; Wang, MW (corresponding author), ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.; Yang, DH; Wang, MW (corresponding author), Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Yang, DH; Wang, MW (corresponding author), Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Wang, MW

BIOSCIENCE REPORTS, 2021; 41 (6):

Abstract

Glucagon plays an important role in glucose homeostasis and amino acid metabolism. It regulates plasma amino acid levels which in turn modulate glucag......

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