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Drd2 biased agonist prevents neurodegeneration against NLRP3 inflammasome in Parkinson's disease model via a beta-arrestin2-biased mechanism

Zhu, JL; Sun, T; Zhang, J; Liu, Y; Wang, DS; Zhu, H; Yao, H; Ding, JH; Hu, G; Lu, M

Hu, G; Lu, M (corresponding author), Nanjing Med Univ, Dept Pharmacol, Jiangsu KeyLab Neurodegenerat, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.

BRAIN BEHAVIOR AND IMMUNITY, 2020; 90 (): 259

Abstract

Activated astrocytes secrete inflammatory cytokines such as interleukin-1 beta (IL-1 beta) into the extracellular milieu, damaging surrounding neurons......

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