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Reversible Assembly of Proteolysis Targeting Chimeras

Gui, WJ; Giardina, SF; Balzarini, M; Barany, F; Kodadek, T

Kodadek, T (通讯作者),Herbert Wertheim UF Scripps Inst Biomed Innovat &, Dept Chem, Jupiter, FL 33458 USA.;Barany, F (通讯作者),Weill Cornell Med, Dept Microbiol & Immunol, New York, NY 10065 USA.

ACS CHEMICAL BIOLOGY, 2023; 18 (7): 1582

Abstract

PROteolysis TArgeting Chimeras (PROTACs) are of significantcurrentinterest for the development of probe molecules and drug leads. However,they suffer ......

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