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Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2

Liu, CJ; Lin, J; Langevine, C; Smith, D; Li, JQ; Tokarski, JS; Khan, J; Ruzanov, M; Strnad, J; Zupa-Fernandez, A; Cheng, LH; Gillooly, KM; Shuster, D; Zhang, YF; Thankappan, A; McIntyre, KW; Chaudhry, C; Elzinga, PA; Chiney, M; Chimalakonda, A; Lombardo, LJ; Macor, JE; Carter, PH; Burke, JR; Weinstein, DS

Liu, CJ (corresponding author), Bristol Myers Squibb Res & Dev, Immunosci Discovery Chem, Princeton, NJ 08543 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (1): 677

Abstract

A search for structurally diversified Tyk2 JH2 ligands from 6 (BMS-986165), a pyridazine carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibi......

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