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Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats

Zhu, Y; Gu, ZQ; Liao, YW; Li, S; Xue, YY; Firempong, MA; Xu, Y; Yu, JN; Smyth, HDC; Xu, XM

Xu, XM (通讯作者),Jiangsu Univ, Ctr Nano Drug Gene Delivery & Tissue Engn, Sch Pharm, Dept Pharmaceut, Zhenjiang 272073, Jiangsu, Peoples R China.;Smyth, HDC (通讯作者),Univ Texas Austin, Coll Pharm, 2409 West Univ Ave,PHR 4-274, Austin, TX 78712 USA.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2022; 102 (3): 1002

Abstract

BACKGROUND Astaxanthin (ASTA) is a kind of food-derived active ingredient (FDAI) with antioxidant and antidiabetic functions. It is nontoxic but its p......

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