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Non-Heme Monooxygenase ThoJ Catalyzes Thioholgamide beta-Hydroxylation

Sikandar, A; Lopatniuk, M; Luzhetskyy, A; Koehnke, J

Koehnke, J (corresponding author), Saarland Univ, Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Workgrp Struct Biol Biosynthet Enzymes, D-66123 Saarbrucken, Germany.; Luzhetskyy, A (corresponding author), Saarland Univ, Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Actinobacteria Metab Engn Grp,Dept Microbial Nat, D-66123 Saarbrucken, Germany.; Koehnke, J (corresponding author), Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland.

ACS CHEMICAL BIOLOGY, 2020; 15 (10): 2815

Abstract

Thioviridamide-like compounds, including thioholgamides, are ribosomally synthesized and post-translationally modified peptide natural products with p......

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